This study presents two methods to simulate landslide-generated wave problems. First, a holistic Particle Finite Element Method (PFEM) [1] formulation is applied for the simulation of the entire multi-hazard scenario, including landslide runout, the impact on water reservoirs, wave generation and propagation in the water basin, and the final runup. The accuracy of this model is tested against large-scale laboratory tests and other numerical results from the literature. The method is also applied to the analysis of the Vajont disaster [2, 3]. In the second method, the PFEM is combined with an Eulerian Shallow Water model. First, the PFEM is used to solve the near field problem, i.e. from landslide motion to wave generation. To reduce the computational cost of the analysis, this problem is solved for a smaller domain and for a reduced time duration. During this analysis, the kinematic variables of the generated water waves are stored at a selected interface. This information is then transferred to the Shallow Water solver, which is used to model wave propagation only [4]. Another one-way coupling procedure is then applied in the shoreline zone. Here, the shallow-water solution is used as input for a new PFEM analysis, which is used for modelling the run-up of water and its interaction with coastal civil constructions. Several numerical tests are presented to demonstrate the accuracy of this coupled scheme and to highlight the significant gain in terms of computational cost compared to the holistic approach. REFERENCES [1] M. Cremonesi, A. Franci, S.R. Idelsohn, E. Oñate, A state of the art review of the Particle Finite Element Method (PFEM), Archives of Computational Methods in Engineering, 17:1709-1735, (2020). [2] A. Franci, M. Cremonesi, U. Perego, G. Crosta, E. Oñate, 3D numerical simulation of the Vajont disaster. Part 1: Numerical formulation and validation, Engineering Geology, 279:105854, (2020). [3] A. Franci, M. Cremonesi, U. Perego, E. Oñate, G. Crosta, 3D numerical simulation of the Vajont disaster. Part 2: Multi-failure scenarios, Engineering Geology, 279:105856, (2020). [4] M. Masó, A. Franci, I. de-Pouplana, A. Cornejo, E. Oñate, A Lagrangian-Eulerian procedure for the coupled solution of the Navier-Stokes and shallow water equations for landslide-generated waves, Advanced Modeling and Simulation in Engineering Sciences, 9 (15), 2022.